Following 1 year of treatment, XENICAL in combination with diet was shown to be more effective in reducing weight than diet alone. In most cases, weight loss was gradual. Patients treated with XENICAL and a reduced-calorie diet for 1 year lost an average of 13.4 lbs, while those on a reduced-calorie diet alone lost 5.8 lbs. And XENICAL helped more people lose weight. In fact, over twice as many XENICAL patients lost 10% of their body weight, and among those who did, the average weight loss was 31 lbs and the range of weight loss was between 16 and 74 lbs.